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Min Zhuo
Min Zhuo (born 1964) is a pain neuroscientist at the University of Toronto in Canada. He is also the Michael Smith Chair in Neuroscience and Mental Health as well as the Canada Research Chair in Pain and Cognition and a Fellow of the Royal Society of Canada.
== Education ==
Zhuo was born in 1964 in Xiapu. At the age of 16, he was admitted to the University of Science and Technology of China in Hefei — graduating in 1985. At the University of Iowa, he completed his PhD in Jerry Gebhart's () laboratory. In 1992, Zhuo joined Eric Kandel's laboratory at Columbia University where he showed CO-cGMP as key messengers for presynaptic LTP.〔Zhuo M, Small SA, Kandel ER, Hawkins RD (1993). Nitric oxide and carbon monoxide produce activity-dependent long-term synaptic enhancement in hippocampus. Science 260, 1946-1950〕 In 1995, Zhuo spent one year in Richard Tsien's laboratory at Stanford University. In 1996, Zhuo moved to Washington University in St. Louis and focused on pain plasticity in the spinal cord and cortex. He showed that 'smart' mice suffered more pain,〔Wei F, Wang GD, Kerchner GA, Kim SJ, Xu HM, Chen ZF, Zhuo M (2001). Genetic enhancement of inflammatory pain by forebrain NR2B overexpression. Nat Neurosci 4, 164-169.〕 GluN2B and AC1 are novel therapeutic targets for treating chronic pain〔Wei F, Qiu CS, Kim SJ, Muglia L, Maas JW, Pineda VV, Xu HM, Chen ZF, Storm DR, Muglia LJ, Zhuo M (2002). Genetic elimination of behavioral sensitization in mice lacking calmodulin-stimulated adenylyl cyclases.〕〔Wei F, Qiu CS, Kim SJ, Muglia L, Maas JW, Pineda VV, Xu HM, Chen ZF, Storm DR, Muglia LJ, Zhuo M (2002). Genetic elimination of behavioral sensitization in mice lacking calmodulin-stimulated adenylyl cyclases. Neuron 36, 713-726.〕 In 2003, he moved to the University of Toronto, and identified NB001 as a selective inhibitor for AC1.〔Wang H, Xu H, Wu LJ, Kim SS, Chen T, Koga K, Descalzi G, Gong B, Vadakkan KI, Zhang X, Kaang BK, Zhuo M. (2011) Identification of an adenylyl cyclase inhibitor for treating neuropathic and inflammatory pain. Science Translational Medicine, ;3(65):65ra3 (Comment in: Nat Rev Drug Discov. 2011 Mar;10(3):176).〕 He co-established two online journals, ''Molecular Pain'' () and ''Molecular Brain''. In 2009, he was elected to Fellow of Royal Society of Canada.
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